Molecular Machinery of Malaria Infection: Insights into Host-parasite Interactions and Therapeutic Targets
Temesgen Mitiku *
Department of Medical Biotechnology, Dambi Dollo University, Dambi Dollo, Ethiopia.
Betelhem Abebe
Department of Biotechnology, University of Gondar, Gondar, Ethiopia.
*Author to whom correspondence should be addressed.
Abstract
Malaria continues to be a main global health issues, with millions of people affected each year. Understanding the molecular machinery behind malaria infection is crucial for the development of effective therapeutic interventions. This review aims to discuss the lifecycle of the malaria parasite, highlighting the molecular mechanisms of invasion, immune evasion, and sequestration. Furthermore, we delve into the intricate signaling pathways and molecular factors that contribute to malaria-induced immune dysregulation and disease progression. Finally, we explore potential therapeutic targets, including drug resistance mechanisms and novel strategies for intervention. By unraveling the molecular machinery of malaria infection, we hope to provide valuable insights for the development of targeted therapies and the eventual eradication of this devastating disease.
Keywords: Abrupt DNA methylation, Malaria, Orgin of heterospory, molecular mechanisms, Evolutionary Strategies, host-parasite interactions, I. pantil complex., pathogenesis